Modifiers in asc

I am new to ASC coding and have 2 questions:

1. The CPT book states list of ASC modifiers in Appendix A and modifiers 51,22 etc is not there but it is mentioned everywhere including in this forum regarding adding modifiers 51,22 etc (pro-fee modifiers). Can I use these modifiers or not for ASC?

2. What modifier to use for Medi-Cal? AG modifier is denied for ASC. I don't know which modifier for primary procedure and do I add 51 modifier to all procedures after primary procedure?

Modifiers in asc